An Efficient Stereoselective Total Synthesis of Synargentolide A and Its Epimer

✍ Scribed by Biswanath Das; Penagaluri Balasubramanyam; Boyapati Veeranjaneyulu; Gandolla Chinna Reddy

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 132 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000342

✦ Synopsis

Abstract

The stereoselective total synthesis of a naturally occurring α‐pyrone (=2__H__‐pyran‐2‐one) derivative, synargentolide A (1), and of its epimer 2 (with the originally proposed structure of synargentolide A) was efficiently accomplished involving D‐tartaric acid as the starting material and an olefin cross‐metathesis reaction as the key step.