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An efficient route to 3-substituted cyclobutanone derivatives

✍ Scribed by George W. Kabalka; Min-Liang Yao

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 126 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00081-9

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✦ Synopsis

An efficient route to 3-(hydroxymethyl)cyclobutanone acetals via a [2+2] cycloaddition reaction is reported. The dramatic effect of different diol acetals on benzyl deprotection is discussed. Efficient synthesis of two synthetically useful intermediates, 3-methylenecyclobutanone acetal and 3-(bromomethyl)cyclobutanone, are provided.

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## Abstract For Abstract see ChemInform Abstract in Full Text.