An efficient, recoverable fluorous organocatalyst for accelerating the DABCO-promoted Morita–Baylis–Hillman reaction

✍ Scribed by Yi Bo Huang; Wen Bin Yi; Chun Cai

• Book ID: 104010591
• Publisher: Chinese Electronic Periodical Services
• Year: 2011
• Tongue: English
• Weight: 157 KB
• Volume: 22
• Category: Article
• ISSN: 1001-8417
• DOI: 10.1016/j.cclet.2011.03.010

✦ Synopsis

A convenient method for Morita-Baylis-Hillman reaction of arylaldehydes with methyl acrylate has been developed by using fluorous-tag organocatalyst 1-[4-(perfluorooctyl)phenyl]-3-phenylthiourea and DABCO at room temperature. The fluorous organocatalyst could be recovered from the reaction mixture by fluorous solid-phase extraction (F-SPE) with excellent purity for direct reuse.