An efficient protocol for the one-pot synthesis of 4-(2-(4-bromophenyl)-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-2(1H)-ones/thiones catalyzed by Mg(NO3)2

✍ Scribed by Chenjiang Liu; Xinhai Zhao; Yanping Li

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 72 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.517

✦ Synopsis

Abstract

A series of novel 4‐(2‐(4‐bromophenyl)‐1,2,3‐triazol‐4‐yl)‐3,4‐dihydropyrimidin‐2(1__H__)‐ones/thiones were prepared by condensing 2‐(4‐bromophenyl)‐4‐formyl‐1,2,3‐triazole with 1,3‐dicarbonyl compound and urea or thiourea using Mg(NO~3~)~2~ as an efficient and cheap catalyst. The satisfactory results were obtained with excellent yields and short reaction time. J. Heterocyclic Chem., (2010).