An efficient protocol for multicomponent synthesis of spirooxindoles employing L-proline as catalyst at room temperature
β Scribed by Dushyant Singh Raghuvanshi; Krishna Nand Singh
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 88 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.451
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β¦ Synopsis
Abstract
magnified image An efficient threeβcomponent oneβpot synthesis of medicinally important spirooxindoles is described by the reaction of isatin, malononitrile/ethyl cyanoacetate, and dimedone/barbituric acid using Lβproline as catalyst in ethanol at room temperature. This approach is convenient, mild, and affords the products in high yields without the use of chromatography. J. Heterocyclic Chem., (2010).
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