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An efficient protocol for multicomponent synthesis of spirooxindoles employing L-proline as catalyst at room temperature

✍ Scribed by Dushyant Singh Raghuvanshi; Krishna Nand Singh


Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
88 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

magnified image An efficient three‐component one‐pot synthesis of medicinally important spirooxindoles is described by the reaction of isatin, malononitrile/ethyl cyanoacetate, and dimedone/barbituric acid using L‐proline as catalyst in ethanol at room temperature. This approach is convenient, mild, and affords the products in high yields without the use of chromatography. J. Heterocyclic Chem., (2010).


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