An efficient partial synthesis of (+)-artemisinin and (+)-deoxoartemisinin

✍ Scribed by Peter T. Lansbury; Deanne M. Nowak

• Publisher: Elsevier Science
• Year: 1992
• Tongue: French
• Weight: 298 KB
• Volume: 33
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)91851-3

✦ Synopsis

Arteannuic acid and arteannuin B are separately convertible into intermediate 8, which is transformed by four or five high-yielding steps into the title anti-malarial sesquiterpsne peroxides. The outstanding anti-malarial properties of artemisinin (1 )' and derivatives preparable therefrom (e.g. 2,'3*) have prompted extensive synthetic efforts to supplement the small amountsla of 1 typically isolable from the leaves of Aft8fniSia annua L.