An efficient one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol- 5-yl)amides

✍ Scribed by Wei-Nien Su; Tsung-Ping Lin; Kaung-Min Cheng; Kuan-Chin Sung; Shao-Kai Lin; Fung Fuh Wong

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 131 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.343

✦ Synopsis

Abstract

magnified image A “one‐pot” method for the synthesis of N‐(1,3‐diphenyl‐1__H__‐pyrazol‐5‐yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N‐(1,3‐diphenyl‐1__H__‐pyrazol‐5‐yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work‐up procedure without isolation and purification of intermediary 5‐amino‐1,3‐diphenyl pyrazol (2). J. Heterocyclic Chem., (2010).