An efficient one-pot solvent-free synthesis of 2,3-dihydroquinazoline-4(1H)-ones via Al/Al2O3 nanoparticles

✍ Scribed by M. Z. Kassaee; Shahnaz Rostamizadeh; Nasrin Shadjou; Elahe Motamedi; Maryam Esmaeelzadeh

• Book ID: 102344987
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 200 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.506

✦ Synopsis

An efficient one-pot, solvent-free method is reported for the synthesis of 2-phenyl-2,3-dihydroquinazoline-4(1H)-one as well as its o-Cl, o-OMe, m-Br, m-NO 2 , p-OH, p-NO 2 , p-CN, p-PhCH 2 O, p-Cl, p-F, p-Br, p-Me, and o,m-dichloro derivatives, using our ''as-prepared'' arc discharge fabricated Al/Al 2 O 3 nanoparticles. Compared with our previous report and other known methods, this route gives higher yields with shorter reaction times, whereas its green catalyst appears recyclable at least four times-with minor decrease in its catalytic activity, under mild conditions.