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An efficient one-pot four-step domino reaction for the synthesis of C2-substituted 3-methylcyclohex-2-enones

โœ Scribed by Sylvie Goncalves; Philippe Maillos; Marc Nicolas; Alain Wagner; Rachid Baati


Book ID
108283374
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
444 KB
Volume
66
Category
Article
ISSN
0040-4020

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A novel and efficient protocol is developed for the synthesis of various spiro-2-amino pyrimidinones via the three-component condensation of alkyl cyanoacetates, guanidinium carbonate and N-substituted 4-piperidinones in ethanol at reflux. High yields, neutral conditions, and short reaction times ar