An efficient MR phosphorous spectroscopic localization technique for studying ischemic heart
✍ Scribed by Haiying Liu; Jianyi Zhang
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 197 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
To obtain the spatially resolved 31 P spectroscopic image from myocardium during an acute myocardium ischemia at a high signal-to-noise ratio (SNR) in a very limited time window, we have exploited the spatial variation of the radiofrequency (RF) field produced by a single loop transmit/receive (TR) RF coil along its axis for spatial discrimination. By incrementally lengthening the duration of a square RF excitation pulse, the positional information can be systematically encoded as harmonics of various orders in MR signal. In the in vivo open-chest animal experiment, this RF coil was surgically sutured onto the epicardial surface of the left ventricular (LV) wall over the region perfused by the left anterior descending coronary artery. Using only 17 encoding steps, we have obtained onedimensional 31 P spectroscopic images from both a multiplelayer phosphor phantom and an in vivo LV myocardium. In the animal study, the cardiac gating is used with respiratory synchronization. The MR data were only collected during the end diastole phase of the cardiac cycle (cardiac and respiratory synchronized) with an effective sequence repetition time (TR) of 6 seconds (to ensure the complete relaxation of the phosphorous magnetization). The total acquisition time for a complete experiment is about 10 minutes. Prior to the CSI reconstruction process, the raw data matrix was zero-filled in the spatial dimension. The spatially resolved metabolite map exhibited all the metabolite peaks including creatine phosphate and adenosine triphosphate. At the layer of endocardium, two peaks corresponding to 2,3-diphosphoglycerate, which is contained in the erythrocytes, were clearly seen in the LV wall. Also, the method allows compensation in both volume and coil sensitivity variations for the resulting spectra. All results have demonstrated that it is an efficient nuclear magnetic resonance method capable of obtaining highquality 31 P spectroscopic images with both excellent spatial localization and SNR in the research of cardiac ischemia.