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An efficient microwave-assisted synthesis of 6,8-dihydroimidazo[1,2-a] [1,3,5] triazine derivatives

✍ Scribed by Mitra Matloobi; Hans Wolfgang Schramm

Book ID: 102343989
Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 87 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.378

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✦ Synopsis

Abstract

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A simple, efficient, and general method has been developed for the synthesis of various 4‐substituted 2‐amino‐6,6‐diphenyl‐8‐aryl‐6,8‐dihydroimidazo[1,2‐a] [1,3,5] triazine‐7(4‐H)ones 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o, 3p, 3q, 3r, 3s, 3t, 3v. This involved condensation of 1‐(5‐oxo‐4,4‐diphenyl‐1‐aryl‐4,5‐dihydro‐1__H__‐imidazol‐2‐yl)guanidines 2a and 2b, themselves obtained from the reaction of aryl biguanides 1a/b with benzil, with the requisite carbonyl compounds. Both steps were performed using microwave heating in sealed vessels. J. Heterocyclic Chem., (2010).

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