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An efficient method for the synthesis of (R)-3-(1-amino-1-methylethyl)pyrrolidines for the antiinfective agent, PD 138312

✍ Scribed by Victor Fadij; Edward A. Lenoir III; Mark J. Suto; James R. Zeller; James Wemple


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
255 KB
Volume
5
Category
Article
ISSN
0957-4166

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Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with aldehydes and ketones to produce homopropargyl alcohols in a single step route and