β Scribed by Kirk R. Maples; Jennifer L. Lane; Alan R. Dahl
No coin nor oath required. For personal study only.
Epoxides are known mutagenic and carcinogenic metabolites of alkenes. During current toxicological investigations in our laboratory, we have monitored in vivo epoxide levels using gas chromatography/mass spectroscopy isotope dilution assays. These assays require the use of deuterated analogues for the expected epoxide metabolites. To determine whether butadiene monoepoxide is formed in vivo following inhalation of 1,3βbutadiene, deuterated butadiene monoepoxide, a compound that is not commercially available, was needed. To meet this need, we developed a method using monoperoxyphthalic acid to synthesize [d~6~]βbutadiene monoepoxide from [d~6~]β1,3βbutadiene with a reaction time of 50 min and a 94% yield.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Two types of naphtho-fused 1,3-dithiole-2-thiones (2a-f and 4a were confirmed by X-ray investigation. The tetrathiafulvalenes (TTFs) 6 and 7 were synthesized from 2d 4a-d) were obtained by the reaction of 3,4,7,8-tetrachloronaphtho[1,8-cd:5,6-cΠdΠ]bis(1,2-dithiole) (1) and sodium and 3c by coupling
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v