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An Efficient Large-Scale Synthesis of Methyl 5-[2-(2,5-Dimethoxyphenyl)ethyl]-2-hydroxybenzoate

✍ Scribed by Kucerovy, Andrew; Li, Tangqing; Prasad, Kapa; Repič, Oljan; Blacklock, Thomas J.


Book ID
120085124
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
186 KB
Volume
1
Category
Article
ISSN
1083-6160

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An expedient synthesis of ortho-methoxy substituted 9-keto-5-phenylmorphans has been developed, featuring a Thorpe-Zieger cyclization to construct the substituted 2-phenylcyclohexanone intermediate.