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An efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph3PAuOTf

✍ Scribed by Yao Li; You Yang; Biao Yu

Book ID
104095303
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
130 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new and powerful glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors and Ph 3 PAuOTf as a promoter is disclosed. The donors are readily available and stable; the glycosidic coupling yields are generally excellent; the promotion system is catalytic, neutral, and orthogonal to the known glycosylation conditions.

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✍ Yao Li; Xiaoyu Yang; Yunpeng Liu; Cunsheng Zhu; You Yang; Biao Yu πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 479 KB πŸ‘ 1 views

## Abstract Glycosyl __ortho__‐alkynylbenzoates have emerged as a new generation of donors for glycosidation under the catalysis of gold(I) complexes such as Ph~3~PAuOTf and Ph~3~PAuNTf~2~ (Tf=trifluoromethanesulfonate). A wide variety of these donors, including 2‐deoxy sugar and sialyl donors, are