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An efficient gene transfer system for hematopoietic cell line using transient and stable vectors

✍ Scribed by Leonardo Augusto Karam Teixeira; Cecília Helena Fricke; Cristina Beatriz Bonorino; Maurício Reis Bogo; Nance Beyer Nardi


Book ID
119524009
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
143 KB
Volume
88
Category
Article
ISSN
0168-1656

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## Abstract ## Background A paucity of coxsackie adenovirus receptor (CAR) hampers the adenovirus serotype 5 (Ad5)‐based vector‐mediated gene transfer into malignant hematopoietic cells. Fiber‐retargeted adenoviral vectors with species B tropism can potentially bypass the CAR requirement and facil