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An Efficient, Convenient Solid-Phase Synthesis of Amino Acid-Modified Peptide Nucleic Acid Monomers and Oligomers

✍ Scribed by Balaji, Baghavathy S.; Gallazzi, Fabio; Jia, Fang; Lewis, Michael R.


Book ID
126860267
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
109 KB
Volume
17
Category
Article
ISSN
1043-1802

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Solid-phase synthesis of peptide nucleic
✍ Gudrun Aldrian-Herrada; Alain Rabié; Reinhold Wintersteiger; Jean Brugidou 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

A new simple solid-phase method has been developed for synthesizing Boc-protected peptide nucleic acid (PNA) monomers. An immobilized backbone 3 was built on Expansin ® resin using an ester disulphide handle: 2-hydroxypropyl-dithio-2%-isobutyric acid (HPDI). The base acetic acids of thymine 5, Z-cyt