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An Efficient Catalytic Asymmetric Synthesis of a β 2 -Amino Acid on Multikilogram Scale

✍ Scribed by Remarchuk, Travis; Babu, Srinivasan; Stults, Jeffrey; Zanotti-Gerosa, Antonio; Roseblade, Stephen; Yang, Shaohui; Huang, Ping; Sha, Chunbo; Wang, Youchu


Book ID
121436931
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
897 KB
Volume
18
Category
Article
ISSN
1083-6160

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An efficient approach to asymmetric synt
✍ Wei Wang; Chiyi Xiong; Victor J Hruby 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 68 KB

Azabicyclo[X.Y.0] alkane amino acids are rigid dipeptide b-turn mimetics with great potential applications for drug discovery. The lack of efficient methods to synthesize these compounds is a major bottleneck in this field. Herein we report an efficient approach to the enantiopure synthesis of (3S,6