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An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

โœ Scribed by Lushi Tan; Cheng-yi Chen; Robert D. Larsen; Thomas R. Verhoeven; Paul J. Reider

Book ID
104259311
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
206 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

An efficient enantioselective synthesis of L-784,512 featuring a Horner-Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.

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