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An efficient approach to the synthesis of tri-substituted iminothiazolidenes and their effects on the human neuroblastoma cell line

✍ Scribed by Muhammad Saeed; Muhammad Abbas; Angelica Heinrich; Wolfgang Voelter

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 187 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01457-6

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✦ Synopsis

Starting from cis-oriented epoxytriflate pentoses 1 and 4, an expeditious route to the chiral thioazolidene derivatives 2a-3a and 5a-6a in good yields is described. A minor amount of structural isomers 2b-3b and 5b-6b has also been observed. The newly formed compounds show activity against the human neuroblastoma cell line SK-N-LO.

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