Disarmed glycosyl trichloroacetimidates can be activated by Yb(OTf) 3 in the synthesis of 1,2-trans glycosides involving primary and secondary acceptors. Concurrent formation of orthoester side products can be avoided by the use of alkoxycarbonyl groups for the protection of the donor 2-hydroxyl.
An efficient approach to O-glycosides through CuBr2-Bu4NBr mediated activation of glycosides
β Scribed by Susumu Sato; Masato Mori; Yukishige Ito; tomoya Ogawa
- Book ID
- 108309042
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 294 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0008-6215
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## N-iodosuccinimide (ND) in the presence of an organic acid was found to be effective for the activation of fully acylated thioglycosides leading to J&trans linked esters. On the other hand, NIS together with a catalytic amount of tri#luoromethanesu&onic acid proved to be very convenient for the ra
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