An efficient approach for total synthesis of aminopropyl functionalized ganglioside GM1b
β Scribed by Sun, Bin; Jiang, Heyan
- Book ID
- 123398748
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 975 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
First total synthesis of extended gun@-ganglioside IV4GalNAc8GMlb. 8-D-GalpNAc-(l~4)-[a-D-Neup5Ac-(2~3)]-~-D-Galp-(l~3)-~-D-Gal~NAc-(l~4)-~-D-Galp-(1~4)-B\_D-Glcp-(l+ I)-Cer was achieved in a stereocontrolled manner. In 1981, a new gangfio-monosialylpentaosylceramide. was isolated from Tay-Sachs br
Gangliosides, sialic acid containing glycosphingolipids, are a class of structurally diverse molecules commonly present in vertebrate plasma membranes and especially enriched in nerve tissues\*. These membrane components are thought to be responsible for important physiological activities, and it is
We have developed an efficient methodology for highly stereoselective sialylation using 3-position substituted sialic acids and have prepared 2a having a 3fl-phenylthio group as a sialic donor. Glycosylation of suitably protected lactoside 3 with 2a gave only the a-sialyl trisaccharide 16 in good yi
A first total synthesis of ganglia ganglioside GMlb. a-D-NeupSAc-(243)~8-D-Galp-(1-+3)-~-D-GalpNAc-(l~4)-P\_D-Galp-(l~4)-~-D-Glcp-(l~l)-Cer, was achieved in a stereocontrolled manner.