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An Efficient and Practical Synthesis of Benzoxazoles from Acyl Chlorides and 2-Aminophenols Catalyzed by Lewis Acid In(OTf)3 under Solvent-Free Reaction Conditions

✍ Scribed by Bo Wang; Yicheng Zhang; Pinhua Li; Lei Wang

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
117 KB
Volume
28
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

Benzoxazole derivatives have been prepared through the reaction of substituted 2‐aminophenols and acyl chlorides in the presence of catalytic amount of In(OTf)~3~ under solvent‐free reaction conditions in good to excellent yields. The method is simple, convenient, environmental‐friendly, efficient and practical.

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