𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An efficient and practical method for the synthesis of mono-N-protected α,ω-diaminoalkanes

✍ Scribed by Jae Wook Lee; Sung Im Jun; Kimoon Kim

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
61 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) a,v-diaminoalkanes (the number of carbon atoms=3, 4, 5 and 6) are accomplished in 81-94% yield by the protection of amine and subsequent reduction of an azido group from a,v-azido alkyl amines. a,v-Azido alkyl amines are prepared efficiently by the partial reduction of a,v-diazidoalkanes which are obtained from the corresponding dibromoalkanes.

📜 SIMILAR VOLUMES

ChemInform Abstract: An Efficient and Pr
ChemInform Abstract: An Efficient and Practical Method for the Synthesis of Mono-N-Protected α,ω-Diaminoalkanes.
✍ Jae Wook Lee; Sung Im Jun; Kimoon Kim 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

An improved practical synthesis of prote
An improved practical synthesis of protected α-amino selenocarboxylates and its application to the synthesis of N-(α-aminoacyl)sulfonamides
✍ Xinghua Wu; Yu Chen; Longqin Hu 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 959 KB

An improved practical synthetic method was developed for the preparation of selenocarboxylates of amino acids through the reaction of the corresponding activated esters with sodium hydrogen selenide in alcoholic or aqueous medium. The protected a-amino selenocarboxylates reacted readily with sulfony

Nα-Fmoc-Protected ω-Azido- and ω-Alkynyl
Nα-Fmoc-Protected ω-Azido- and ω-Alkynyl-L-amino Acids as Building Blocks for the Synthesis of “Clickable” Peptides
✍ Alexandra Le Chevalier Isaad; Francesca Barbetti; Paolo Rovero; Anna Maria D'Urs 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 1 views

## Abstract The growing interest in the 1,4‐disubstituted‐1,2,3‐triazolyl moiety as an amide bond surrogate and its formation through very mild, chemoselective, and bioorthogonal Cu^I^‐catalyzed Huisgen 1,3‐dipolar [3+2] cycloaddition of an alkynyl to an azido function, presented an unmet need for