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An efficient and green synthesis of phthalide-fused pyrazole and pyrimidine derivatives

โœ Scribed by Motamedi, Anahita; Sattari, Elahe; Mirzaei, Peiman; Armaghan, Mahsa; Bazgir, Ayoob


Book ID
121676172
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
1007 KB
Volume
55
Category
Article
ISSN
0040-4039

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A new and efficient route to the synthes
โœ Augusto C Veronese; Carlo F Morelli ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 191 KB

A new route to the synthesis of pyrazole and pyrimidine C-nucleosides, involving as the key step a metal catalysed reaction of [3-D-ribofuranosyl ketoesters with alkyl cyanoformates, is described. 2,3,5-Tri-O-benzoyl-13-D-ribofuranosyl cyanide (1) reacts with ยขt-bromoesters, in the presence of zinc