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An Efficient and Convenient Synthesis of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridines by a Modified Pictet-Spengler Reaction via a Formyliminium Ion Intermediate

✍ Scribed by Horiguchi, Yoshie; Kitabatake, Michikazu; Hashimoto, Aki; Saitoh, Toshiaki; Sano, Takehiro; Mohri, Kunihiko

Book ID
115464988
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
785 KB
Volume
81
Category
Article
ISSN
0385-5414

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ChemInform Abstract: An Efficient and Co
ChemInform Abstract: An Efficient and Convenient Synthesis of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridines by a Modified Pictet—Spengler Reaction via a Formyliminium Ion Intermediate.
✍ Michikazu Kitabatake; Aki Hashimoto; Toshiaki Saitoh; Takehiro Sano; Kunihiko Mo 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract The Pictet‐Spengler reaction is performed as a one‐pot procedure by condensing thienylethylamine (I) with carbonyl compounds (II), followed by treatment of the in situ formed imines with acetic‐formic anhydride (III) to produce a formyliminium ion, which upon treatment with TFA cyclizes