An efficient algorithm to compute marginal posterior genotype probabilities for every member of a pedigree with loops

An efficient algorithm to compute the po

An efficient algorithm to compute the posterior genotypic distribution for every member of a pedigree without loops

✍ R. L. Fernando; C. Stricker; R. C. Elston 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 450 KB

This paper describes a non-iterative, recursive method to compute the likelihood for a pedigree without loops, and hence an efficient way to compute genotype probabilities for every member of the pedigree. The method can be used with multiple mates and large sibships. Scaling is used in calculations