An efficient 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU)-mediated synthesis of 5-(trifluoromethyl)-N-alkyl-1-(3-phenylisoquinoline-1-yl)-1H-pyrazole-4-carboxamides
โ Scribed by K. Prabakaran; F. Nawaz Khan; Jong Sung Jin
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 335 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0922-6168
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๐ SIMILAR VOLUMES
2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) has been adapted for use as a coupling reagent for tert-butyloxycarbonyl (Boc) amino acids in automated solid-phase peptide synthesis. When compared to the existing preformed symmetrical anhydride procedure employing dicycl
This study describes, firstly, the synthesis of a new precursor, 4,6,6-trimethoxy-1,1,1-trifluorohex-3-en-2-one (1), from the trifluoroacetylation reaction of 1,1,3,3-tetramethoxybutane, in 65% yields. Afterwards, the reaction of 1 with two hydrazines (NH 2 NHR, where R = 2-furanoyl, C 6 F 5 ) led t