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An Effective and Convenient Method for the Preparation of KAD-1229

✍ Scribed by Jianchao Liu; Yushe Yang; Ruyun Ji

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
110 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A new convenient method for the asymmetric synthesis of the potent hypoglycemic agent KAD‐1229 was developed. The key step of this method is diasteroselective alkylation of 1 to give crude 2 (d.e.>93%) in good yield with the easily available Oppolzer's camphorsultam as chiral auxiliary. The overall yield of the product was 57%.

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