An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations
✍ Scribed by Susanne Timshel; Christina Therkildsen; Pär-Ola Bendahl; Inge Bernstein; Mef Nilbert
- Book ID
- 108078786
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 136 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1877-7821
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## Abstract HNPCC is an autosomal dominantly inherited cancer‐susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to colorectal cancer and other malignancies. The evaluation of many questions regarding HNPCC requires clinically and genetically well-characterized HNPCC patient cohorts of reas