✦ LIBER ✦

An autonomous cell-cycle oscillator involved in the coordination of G1 events

✍ Scribed by Marc R. Roussel

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 51 KB
Volume: 22
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(200001)22:1<3::aid-bies2>3.0.co;2-w

No coin nor oath required. For personal study only.

✦ Synopsis

In early embryonic development, the cell cycle is paced by a biochemical oscillator involving cyclins and cyclindependent kinases (cdks). Essentially the same machinery operates in all eukaryotic cells, although after the first few divisions various braking mechanisms (the so-called checkpoints) become significant. Haase and Reed have recently shown that yeast cells have a second, independent oscillator which coordinates some of the events of the G1 phase of the cell cycle. Although the biochemical nature of this oscillator is not known, it seems unlikely to be a redundant cyclin/cdk system.

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