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An asymmetric total synthesis of (−)-fumagillol

✍ Scribed by Deukjoon Kim; Soon Kil Ahn; Hoon Bae; Won Jun Choi; Hak Sung Kim


Book ID
104257284
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
218 KB
Volume
38
Category
Article
ISSN
0040-4039

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A Concise Synthesis of Fumagillol
✍ David A. Vosburg; Sven Weiler; Erik J. Sorensen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 2 views

A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor