An asymmetric synthesis of β-lactams: on the use of chiral oxazolidones in the Kinugasa reaction

✍ Scribed by Amit Basak; Subhash Chandra Ghosh; Tandra Bhowmich; Amit K Das; Valerio Bertolasi

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 194 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00974-7

✦ Synopsis

Enantiopure cis and trans b-lactams 3a-e and 4a-e, respectively, have been synthesized via cycloaddition between chiral oxazolidinyl propynes 1a-b and nitrones 2a-d, in the presence of cuprous iodide (the Kinugasa reaction).