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An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

✍ Scribed by Fan Fu; Teck-Peng Loh

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
296 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.

πŸ“œ SIMILAR VOLUMES

The Total Synthesis of the Oxopolyene Ma
The Total Synthesis of the Oxopolyene Macrolide RK-397.
✍ Mark J. Mitton-Fry; Aaron J. Cullen; Tarek Sammakia πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons βš– 14 KB πŸ‘ 1 views

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