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An Asymmetric Michael Addition of α,α-Disubstituted Aldehydes to Maleimides Leading to a One-Pot Enantioselective Synthesis of Lactones Catalyzed by Amino Acids

✍ Scribed by Kokotos, Christoforos G.


Book ID
120287891
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
582 KB
Volume
15
Category
Article
ISSN
1523-7060

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Enantioselective synthesis of α,α-disubs
✍ AndréB Charette; Christophe Mellon 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 683 KB

The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.