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An Asymmetric, Chemoenzymatic Synthesis of O-Acetylcyanohydrins.

✍ Scribed by Yuri N. Belokon; A. John Blacker; Lisa A. Clutterbuck; David Hogg; Michael North; Christopher Reeve


Publisher
John Wiley and Sons
Year
2007
Weight
31 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Almond ␀-glucosidase was used to catalyze the synthesis of alkyl ␀-Dglucopyranosides 1b-3b starting from either D-glucose (4) or phenyl-␀-Dglucopyranoside (5) and the racemic alcohols 1a-3a. The enzymic reactions were provided in different acetonitrile/water mixtures [9:1 (v/v) for the reverse hydro