An association between renal cell carcinoma and lymphoid malignancies : A case series of eight patients

✍ Scribed by J. E. Kurtz; F. Maloisel; F. Oberling

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 44 KB
• Volume: 80
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970901)80:5<1005::aid-cncr33>3.0.co;2-c

✦ Synopsis

of NHL response. 3 Moreover, elevated risks of dual these second malignancies (concomitant or very close development of second cancer) could not be explained malignancy may reflect the effects of host susceptibility or shared etiologic factors. Travis et al. reported in by treatment. We have observed 3 cases of concomitant non-Hodgkin's lymphoma and renal cancer. It is a successive article that the increased risks persisted for all second cancers (including RCCs) among the noteworthy that in all our patients, pathologic examination of the renal bulk revealed the presence of both long term survivors of NHL. 4 In light of these facts, there seems to be an associ-malignancies, supporting the hypothesis of a common immunomodulatory factor, such as unregulated cyto-ation between RCC and lymphoid malignancies, not only as second malignancies but also as double pri-kine production. Sakai et al. have shown that renal cell carcinoma could produce interleukin (IL)-6 and maries. However, much remains to be learned concerning the pathogenesis of this rather interesting rela-stimulate concomitant malignant myeloma. 5 Local IL-6 or related cytokine synthesis might also enhance a tionship.

wide range of monoclonal malignant lymphoproliferation. Such an hypothesis does not appear to explain