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An assessment of proliferative and enzyme activity in transitional mucosa adjacent to colonic cancer

✍ Scribed by Michael J. Lawson; Leonie M. White; Peter Coyle; Ross N. Butler; Ian C. Roberts-Thomson; Robert A. J. Conyers


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
575 KB
Volume
64
Category
Article
ISSN
0008-543X

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Differential activation of cell death an
✍ Irene V. Bijnsdorp; Godefridus J. Peters; Olaf H. Temmink; Masakazu Fukushima; F 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 844 KB

## Abstract Trifluorothymidine (TFT) is part of the oral drug formulation TAS‐102. Both 5‐fluorouracil (5‐FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross‐resistance to 5‐FU. Therefore, we examined whether mechanistic differences in cell death