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An aphidicolin-resistant mutant of Chinese hamster ovary cell with altered DNA polymerase and 3′ exonuclease activities

✍ Scribed by Zsigmond Fehér; Nawin C. Mishra


Book ID
113263372
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
491 KB
Volume
1263
Category
Article
ISSN
0167-4781

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## Abstract A mutant (A204) of Chinese hamster ovary cells (CHO‐K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3.3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact ce