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An antigenic chimaera of poliovirus type 1 expressing an epitope from human papillomavirus type 16

✍ Scribed by O. Jenkins; A.N. Gillen; K.L. Burke; J. Cason; D. Patel; P.S. Shepherd; D.J. McCance; J.W. Almond


Book ID
119150391
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
99 KB
Volume
7
Category
Article
ISSN
0264-410X

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## Abstract About 50% of cervical cancers are associated with human papillomavirus type 16 (HPV‐16), and since the HPV‐16 E6 and E7 oncoproteins are constitutively expressed in the tumor cells, they are attractive targets for cytotoxic T lymphocyte (CTL)‐mediated immunotherapy. Nevertheless, only a