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An Anionic Nucleophilic Catalyst System for the Diastereoselective Synthesis of trans -β-Lactams

✍ Scribed by Weatherwax, Anthony; Abraham, Ciby J.; Lectka, Thomas

Book ID
118146150
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
67 KB
Volume
7
Category
Article
ISSN
1523-7060

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✍ Takaji Matsumoto; Toshiyuki Murayama; Shigeru Mitsuhashi; Takashi Miura 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 236 KB

Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int