𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An ancient control of epithelial barrier formation and wound healing

✍ Scribed by Bernard Moussian; Anne E. Uv

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
95 KB
Volume
27
Category
Article
ISSN
0265-9247

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✦ Synopsis

Animal epithelia are lined with apical surface matrices, which protect against pathogens, dehydration and physical damage of the underlying cells. The proteins and polysaccharides that comprise these protective barriers vary greatly within the animal kingdom and have evolved in response to the biological needs of various organisms. Yet the genetic control of barrier formation and its regeneration upon wounding appears conserved between vertebrates and insects that are evolutionary more than several hundred millions of years apart. (1,2) A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans.

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## Abstract Wound healing is a complex and well‐orchestrated biological process. Corneal epithelial cells (CECs) must respond quickly to trauma to rapidly restore barrier function and protect the eye from noxious agents. They express a high level of ß2‐adrenergic receptors but their function is unk