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An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

✍ Scribed by Keita Hamasaki; Myong-Chol Woo; Akihiko Ueno

Book ID
104211000
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
129 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE IIB RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: An Aminoglycoside A
ChemInform Abstract: An Aminoglycoside Antibiotic, Neamine, and Its Aromatic Ring-Substituted Derivatives as Potential Inhibitors for HIV-1 RRE-Rev
✍ Keita Hamasaki; Myong-Chol Woo; Akihiko Ueno πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

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