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AN AMINO ACID DELETION ASSOCIATED WITH THE IgG4b ALLOTYPE OF HUMAN IgG4 MYELOMA PROTEINS

โœ Scribed by C. A. Abel; J. -P. Despont


Book ID
114830207
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
215 KB
Volume
1
Category
Article
ISSN
1744-3121

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The human G1m1 allotype associates with
โœ Stickler, M M; Reddy, A; Xiong, J M; Hinton, P R; DuBridge, R; Harding, F A ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 595 KB

The human G1m1 allotype comprises two amino acids, D12 and L14, in the CH3 domain of IGHG1. Although the G1m1 allotype is prevalent in human populations, โˆผ40% of Caucasiods are homozygous for the nG1m1 allotype corresponding to E12 and M14. Peptides derived from the G1m1 region were tested for their