An Amino Acid Change in Novel Protein D123 Is Responsible for Temperature-Sensitive G1-Phase Arrest in a Mutant of Rat Fibroblast Line 3Y1

Prolongation of duration of G2 arrest de

Prolongation of duration of G2 arrest delays and finally blocks entry into M phase in contrast to stable and reversible G1 arrest: Study of a G1/G2 temperature-sensitive mutant of rat 3Y1 fibroblasts

✍ Hirokazu Zaitsu; Genki Kimura 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 529 KB

Proliferation of 3YltsF121 cells was arrested in GI and G2 phases after a shift up to 3 9 P C (restrictive temperature). Both arrests were reversible: after a shift down to 33.8OC (permissive temperature), these cells effectively entered the next phases. However, the entry into M phase of the G2-arr