An Amine-Promoted Aziridination of Chalcones

✍ Scribed by Yu-Mei Shen; Mei-Xin Zhao; Jiaxi Xu; Yian Shi

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 106 KB
• Volume: 45
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200602586

✦ Synopsis

Aziridines are versatile building blocks that can undergo various synthetically useful transformations and are also an important part of many biologically active molecules. [1] Great efforts and progress have been made in the development of various aziridination methods. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] As part of our general interest in the area of small-ring synthesis from olefins, we have been investigating new methods to prepare aziridines, particularly those without protecting groups on the nitrogen atom, such as the aziridination of electron-deficient olefins with aminimide 1 (Scheme 1).