Removal of cysteinylation from an unpair
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Douglas D. Banks; Himanshu S. Gadgil; Gary D. Pipes; Pavel V. Bondarenko; Vipa H
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Article
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2008
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John Wiley and Sons
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English
⚖ 348 KB
The antibody MAB007 was recently shown to be cysteinylated on an unpaired cysteine residue in the CDR3 variable region. Cysteinylation at this position was not complete and resulted in heterogeneous lots of MAB007 with respect to this posttranslational modification. In this report, a mild redox step