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An alternative stereoselective synthesis of trans-(2R,3R)-3-hydroxypipecolic acid

✍ Scribed by Mansour Haddad; Marc Larchevêque


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
71 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The enantioselective synthesis of trans-(2R,3R)-3-hydroxypipecolic acid 1b is presented, starting from O-protected methyl mandelate as chiral source. The synthesis involved a regioselective intramolecular nucleophilic substitution of an azido epoxide as the key step .


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