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An Alternative Route for Multistep Tumorigenesis in a Novel Case of Hereditary Renal Cell Cancer and a t(2;3)(q35;q21) Chromosome Translocation

✍ Scribed by Daniëlle Bodmer; Marc J. Eleveld; Marjolijn J.L. Ligtenberg; Marian A.J. Weterman; Bert A.P. Janssen; Dominique F.C.M. Smeets; Peter E.J. de Wit; Anke van den Berg; Eva van den Berg; Marianne I. Koolen; Ad Geurts van Kessel

Book ID: 117852436
Publisher: American Society of Human Genetics
Year: 1998
Tongue: English
Weight: 570 KB
Volume: 62
Category: Article
ISSN: 0002-9297
DOI: 10.1086/301888

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Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21)

✍ Daniëlle Bodmer; Marga Schepens; Marc J. Eleveld; Eric F.P.M. Schoenmakers; Ad G 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Abstract Previously, we identified a family with renal cell cancer and a t(2;3)(q35;q21). Positional cloning of the chromosome 3 breakpoint led to the identification of a novel gene, __DIRC2__, that spans this breakpoint. Here we have characterized the chromosome 2 breakpoint in detail and found