Background. The development of new bifunctional chelating agents for the labeling of monoclonal antibodies with radiometals is a desirable goal in the area of radioimmunodetection and radioimmunotherapy of cancer. The authors have developed a new N,S-ligand, N-(S-acetylmercaptoacetyl) (p-NCS)phenyla
✦ LIBER ✦
An alternative approach for labeling monoclonal antibodies with Re-186 and Re-188
✍ Scribed by Mario Marinelli; Licia Minguzzi; Adriano Duatti
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 191 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0969-8043
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## Abstract Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokin